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Urokinase Goat anti-Human, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA136015

Catalog No. 01-672-205


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Description

Description

This antibody has been pre-absorbed with immobilized total human serum proteins to remove non-specific antibodies. This antibody is known to bind human HMW-scuPA (54 kDa), HMW-tsuPA (52 kDa), and LMW-scuPA (33 kDa), completely inhibiting the ability of Urokinase to activate plasminogen. Reconstitute with 1 mL of distilled water and add preservative if preferred.

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer ft.s disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

Urokinase
Polyclonal
PBS with mannitol and no preservative
P00749
ATF, UPA, URK, u-PA
Goat
IgG
500 μg
4° C
Primary
5328
ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Unconjugated
PLAU
Lyophilized
PLAU
Purified native HMW-tcuPA and LMW-scuPA (mixture 50/50), isolated from human urine.
Affinity chromatography
RUO
Antibody
Polyclonal
Human
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