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Urokinase Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA136166

Catalog No. 01-672-115


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Description

Description

Reconstitute with 1 mL of distilled water and add preservative if preferred.

This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer ft.s disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Specifications

Specifications

Urokinase
Polyclonal
Unconjugated
PLAU
Lyophilized
PLAU
Purified native HMW-tcuPA and LMW-scuPA.
Affinity chromatography
RUO
Antibody
Polyclonal
Human
ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Radioimmune Assays, Western Blot
0.5 mg/mL
Antibody with no preservative
P00749
ATF, UPA, URK, u-PA
Rabbit
IgG
500 μg
4° C
Primary
5328
Documents
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