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Uromodulin Rat anti-Mouse, Clone: 774056, Invitrogen™

Rat Monoclonal Antibody

Manufacturer:  Invitrogen MA524374

Catalog No. PIMA524374


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Description

Description

Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

This gene encodes uromodulin, the most abundant protein in normal urine. Its excretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin may act as a constitutive inhibitor of calcium crystallization in renal fluids. Excretion of uromodulin in urine may provide defense against urinary tract infections caused by uropathogenic bacteria. Defects in this gene are associated with the autosomal domit renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.
Specifications

Specifications

Uromodulin
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
Q91X17
UMOD, ADMCKD2, FJHN, HNFJ, HNFJ1, MCKD2, THGP, THP, Tamm-Horsfall glycoprotein, tamm-Horsfall urinary glycoprotein, uromodulin, uromucoid Tamm-Horsfall glycoprotein, uromucoid
Rat
IgG2A
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
22242
Immunohistochemistry (Frozen), Western Blot
774056
Unconjugated
Umod
Lyophilized
UMOD
Mouse myeloma cell line NS0-derived recombit mouse Uromodulin Ser24-Ala618
Protein A/G
RUO
Antibody
Monoclonal
Mouse
Documents
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