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USP22 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA512027

Catalog No. PIPA512027


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Description

Description

This antibody is predicted to react with bovine, mouse and Xenopus and zebrafish based on sequence homology.

Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
Specifications

Specifications

USP22
Polyclonal
PBS with 0.09% sodium azide
Q9UPT9
Ubiquitin carboxyl-terminal hydrolase 22; Ubiquitin thiolesterase 22; Ubiquitin-specific processing protease 22; Deubiquitinating enzyme 22
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
23326
Immunohistochemistry (Paraffin), Western Blot
Unconjugated
USP22
Liquid
USP22
KLH conjugated synthetic peptide between 351-380 amino acids from the C-terminal region of human USP22
Ammonium sulfate precipitation
RUO
Antibody
Polyclonal
Human
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