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UVRAG Rabbit anti-Canine, Chicken, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523215

Catalog No. PIPA523215


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Description

Description

UVRAG is predicted to contain a coiled-coil structure and is likely to be metabolically unstable based on the occurrence of a strong PEST domain. It interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenicity of human colon cancer cells. The gene for UVRAG protein is localized on human chromosome 11q13.5 and complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. The gene has been extremely well conserved during evolution, implying an important role for this gene product in cell metabolism. Chromosomal aberrations involving this gene are associated with left-right axis malformation, and mutations in this gene have been associated with colon cancer. The protein is highly expressed in human brain, lung, kidney and liver.
Specifications

Specifications

UVRAG
Polyclonal
Unconjugated
UVRAG
Liquid
UVRAG
Synthetic peptide (389 KGSRSTIKDNINDKLTEK 406) of UVRAG protein.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Canine, Chicken, Human, Mouse, Non-human primate, Rat
Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q9P2Y5, Q8K245
DHTX, VPS38, p63, UV radiation resistance-associated gene protein, beclin 1 binding protein, disrupted in heterotaxy
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
308846, 419091, 607998, 7405, 78610
Documents
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