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Valproic Acid Mouse anti-Chemical, Clone: VP10-115.2, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA110765

Catalog No. 01-671-995


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Description

Description

MA1-10765 detects Valproic Acid. MA1-10765 has been successfully used in ELISA applications. The MA1-10765 immunogen is Valproic acid, conjugated to KLH.

Valproic acid, valproate sodium, and divalproex belong to the group of medicines called anticonvulsants. They are used to control certain types of seizures in the treatment of epilepsy. Also Valproic acid relieves histone deacetylases (HDACs) dependent transcriptional repression and causes hyperacetylation of histones in cultured cells and in vivo. Valproic acid inhibits HDAC activity in vitro, most probably by binding to the catalytic center of HDACs. Most importantly, valproic acid induces differentiation of carcinoma cells, transformed hematopoietic progenitor cells and leukemic blasts from acute myeloid leukemia patients. More over, tumor growth and metastasis formation are significantly reduced in animal experiments. Therefore, valproic acid might serve as an effective drug for cancer therapy.
Specifications

Specifications

Valproic Acid
Monoclonal
1.35 mg/mL
PBS with no preservative; pH 7.4
2-Propylpentanoic acid; Dipropylacetic acid; Depakene; Depakine; C8H16O2
Valproic acid, conjugated to KLH.
Protein G
RUO
Antibody
Monoclonal
ELISA
VP10-115.2
Unconjugated
Liquid
Mouse
IgG1
500 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
Chemical
Documents
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