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VAMP1 Polyclonal Antibody, Invitrogen™

VAMP1 Antibody, PA1-765, from Invitrogen™. Species Reactivity: Canine, Human, Mouse, Rat; Applications: FACS, ICC, IF, IP, WB.

Manufacturer:  Invitrogen PA1765

Catalog No. PA1765

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

VAMP1 Antibody, PA1-765, from Invitrogen. Species Reactivity: Canine, Human, Mouse, Rat; Applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot.

The vesicle associated membrane proteins (VAMP) or synaptobrevins are calcium binding proteins specific to eukaryotes. VAMPs, along with synaptosomal associated protein of 25 kDa (SNAP-25) and syntaxin, form the core complex of soluble NSF attachment protein receptor (SNARE) proteins that interact with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and alpha-SNAP. These membrane associated proteins play a key role in the regulation of vesicle membrane fusion with the plasma membrane. The Clostridium tetani neurotoxin is a metalloprotease with specificity for VAMP. In Alzheimer’s disease, VAMP levels of all isoforms appear to be significantly lowered. It has been shown that the extreme carboxy-terminus of VAMP-1 is involved in subcellular vesicle targeting.
Host Species: Rabbit
Cross Reactivity: Canine, Human, Mouse, Rat
Isotype: IgG
Immunogen: Synthetic peptide corresponding to residues M(1) S A P A Q P P A E G T E G A A P G(18) C of rat VAMP-2.
Formulation: 100µg purified antibody (1mg/mL) in PBS with 1mg/mL BSA and 0.05% sodium azide
Synonyms: Vesicle Associated Membrane Protein 1, Synaptobrevin
Uniprot Accession: P23763, Q62442, Q63666
Entrez GeneID: 22317, 25624, 486726, 6843
Gene Symbol: VAMP1
PA1-765 detects vesicle associated membrane protein 1 (VAMP-1) from human, canine, mouse and rat tissues. PA1-765 has been successfully used in Western blot and immunoprecipitation procedures. By Western blot, this antibody detects a 15 kDa protein representing VAMP-1 from rat brain whole protein extract. The PA1-765 immunogen is a synthetic peptide corresponding to residues M(1) S A P A Q P P A E G T E G A A P G(18) C of rat VAMP-2. This immunizing peptide (Cat. # PEP-099) is available for use in neutralization and control experiments.
Specifications

Specifications

VAMP1
Polyclonal
100μg purified antibody (1mg/mL) in PBS with 1mg/mL BSA and 0.05% sodium azide
Purified
VAMP1
Synthetic peptide corresponding to residues M(1) S A P A Q P P A E G T E G A A P G(18) C of rat VAMP-2.
100μg
Store at -20°C, Avoid Freeze/Thaw Cycles
Primary
22317, 25624, 486726, 6843
Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Unconjugated
P23763, Q62442, Q63666
Vesicle Associated Membrane Protein 1, Synaptobrevin
Rabbit
IgG
RUO
Primary
Polyclonal
Canine, Human, Murine, Rat
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