VANGL2 Rabbit anti-Canine, Human, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA523207
DescriptionVan Gogh is an alternate name for the Drosophila strabismus protein. Van Gogh like-2 (VANGL2) is a 521 amino acid protein in vertebrates similar to strabismus 1 of Drosophila and a component of the frizzled-dishevelled tissue polarity pathway. It interacts through it ft.s C-terminal region with the N-terminal half of DVL1, DVL2 and DVL3 and is a potent tumour suppressor. It is predomitly involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. It plays a crucial role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. VANGL2 is required for polarization and movement of myocardializing cells and seems to act via RHOA signaling to regulate this process. It is expressed in a wide range of tissues.
|Synthetic peptide (308 YSLGEENSTNNSTGQSRA 325) of Van Gogh like-2 protein.|
|Canine, Human, Mouse, Non-human primate, Rat|
|Immunohistochemistry (Paraffin), Western Blot|
|PBS with 0.05% BSA and 0.05% sodium azide|
|Q9ULK5, Q91ZD4, P84889|
|LPP1, LTAP, STB1, STBM, STBM1, loop-tail protein 1 homolog, loop-tail-associated protein, strabismus 1, van Gogh-like protein 2, vang-like protein 2|
|Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|289229, 57216, 610037, 93840|
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