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VASH1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521148

Catalog No. PIPA521148


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Description

Description

A suggested positive control is human brain tissue lysate. PA5-21148 can be used with blocking peptide PEP-1262.

VASH1 was originally identified as an endothelium-derived vascular endothelial growth factor (VEGF)-inducible angiogenesis inhibitor that acts in a negative feedback manner. VASH1 mRNA is expressed brain, heart, kidney and placenta in the adult, with robust expression in various organs during embryonic development. VASH1 expression in tumor cells and tumor vasculature is silenced by methylation by increased expression of Zeste homolog 2 (EZH2). The increase of EZH2 expression is induced by VEGF stimulation, leading to poor clinical prognosis. Recombit adenovirus expressing VASH prevented tumor angiogenesis and inhibited tumor growth, suggesting that it may be a potentially valuable antitumor therapy in the clinic.
Specifications

Specifications

VASH1
Polyclonal
Unconjugated
VASH1
Liquid
VASH1
A 19 amino acid peptide near the carboxy terminus of human VASH1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q7L8A9, Q8C1W1
KIAA1036; vasohibin-1
Rabbit
IgG
100 μg
4° C
Primary
22846, 238328, 503052
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