AVP Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA129118
PA1-29118 detects Vasopressin from human, and mouse samples. PA1-29118 has been successfully used in immunohistochemistry (paraffin tissue), and Western blot applications. The PA1-29118 immunogen is synthetic peptide corresponding to the C-terminus of human vasopressin. Positive Control: Kidney tubuleAvpr2 is a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. Avpr2 has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. Avpr2 can contract smooth muscle during parturition and lactation. Avpr2 is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. The activity of Avpr2 is mediated by G proteins which activate adenylate cyclase.
|4° C, do not freeze|
|Immunohistochemistry (Paraffin), Western Blot|
|10mM PBS with 0.2% BSA and 0.1% sodium azide; pH 7.4|
|Synthetic peptide corresponding to the C-terminus of human vasopressin recceptor V2|