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VEGFB Mouse anti-Human, Mouse, Clone: 58013, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA523836

Catalog No. PIMA523836


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Description

Description

This antibody recognizes both the VEGF-B167 and VEGF-B186 isoforms. In Western blots, no cross-reactivity with recombit human (rh) VEGF, rhVEGF-C, rhVEGF-D, rhCTGF, rhPlGF, rhLDGF, or rhPDGF is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Vascular endothelial growth factors (VEGFs) are a family of closely related growth factors having a conserved pattern of eight cysteine residues and sharing common VEGF receptors. VEGFs stimulate endothelial cells, induce angiogenesis, promote cell migration, increase vascular permeability, and inhibit apoptosis. VEGFB has structural similarities to VEGF and PIGF and is frequently co-expressed with VEGF. There are two alternatively spliced isoforms of VEGFB: VEGFB 167 and VEGFB 186. VEGFB 167, a highly basic heparin-binding protein, remains with the cell or extracellular matrix whereas, VEGFB 186 is readily secreted. VEGFB stimulates endothelial cell proliferation. VEGFB binds to the tyrosine kinase receptor VEGFR1 (flt1) and does not bind to VEGFR2. Vascular Endothelial Growth Factor B is widely expressed but is most abundant in heart, skeletal muscle, and pancreas. It has been suggested that VEGFB expression in human primary breast cancers is associated with lymph node metastasis. The genes that encode VEGFB have been mapped to chromosome 11q13.
Specifications

Specifications

VEGFB
Monoclonal
0.5 mg/mL
PBS with 5% trehalose and No Preservative
P49765, P49766
Vascular endothelial growth factor B [Precursor], VEGF-B, VEGF-related factor, VRF, VEGFB, VRF
Mouse
IgG1
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
22340, 7423
Immunohistochemistry, Western Blot
58013
Unconjugated
VEGFB
Lyophilized
VEGFB
E. coli-derived recombit human VEGF-B167 Pro22-Arg188
Protein A/G
RUO
Antibody
Monoclonal
Human, Mouse
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