VEGF Mouse anti-Rat, Clone: 123704, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA523769
This antibody shows 50-100% cross-reactivity with recombit mouse (rm) VEGF120, rmVEGF164, recombit human (rh) VEGF121, rhVEGF165, and rhVEGF189 and no cross-reactivity with rmVEGF115. This antibody recognizes an epitope found between amino acids 78-120 of rmVEGF120. This segment is present in all VEGF isoforms except rmVEGF115. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.VEGF (vascular endothelial growth factor) which is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. The VEGF family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis, and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. Studies have shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. Elevated levels of VEGF is linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) also known as Crow-Fukase syndrome which affects multiple organs in the body.
|PBS with 5% trehalose and No Preservative|
|Vascular Endothelial Growth Factor, Vascular Permeability Factor, VEGFA, VPF|
|-20° C, Avoid Freeze/Thaw Cycles|
|ELISA, Western Blot|
|Mouse myeloma cell line NS0-derived recombit rat VEGF164 Ala27-Arg190|
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