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VEGF Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA513297

Catalog No. PIPA513297

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

PA5-13297 targets Vascular Growth Factor (VEGF) in IF and WB applications and shows reactivity with Human samples. The PA5-13297 immunogen is a synthetic peptide between 66-95 amino acids from the N-terminal region of Human VEGF.

VEGF (vascular endothelial growth factor) which is a 45 kDa homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. VEGF has a variety of effects on vascular endothelium, including the ability to promote endothelial cell viability, mitogenesis, chemotaxis, and vascular permeability. The VEGF family currently includes VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and PIGF. VEGF and its receptor system have been shown to be the fundamental regulators in the cell signaling of angiogenesis. Most tumors have the absolute requirement of angiogenesis, and VEGF has been described as the most potent angiogenic cytokine linked to this process. To date 5 different isoforms of VEGF have been described. These isoforms are generated as the result of alternative splicing from a single VEGF gene. These various isoforms have been shown to bind to two tyrosine-kinase receptors flt-1 (VEGFR-1) and flk-1/KDR (VEGFR-2), which have been found to be expressed almost exclusively on endothelial cells. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. Studies have shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis. Elevated levels of VEGF is linked to POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy, Skin changes) also known as Crow-Fukase syndrome which affects multiple organs in the body.
Specifications

Specifications

VEGF
Polyclonal
PBS with 0.09% sodium azide
P15692
Vascular endothelial growth factor A [Precursor]; VEGF-A; Vascular permeability factor; VPF; VEGF; VEGFA; VEGF1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7422
Immunocytochemistry, Immunofluorescence, Western Blot
Unconjugated
VEGFA
Liquid
VEGFA
KLH conjugated synthetic peptide between 66-95 amino acids from the N-terminal region of human VEGF1
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Documents
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