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MilliporeSigma™ anti-VEGFR1, Polyclonal

Goat Polyclonal Antibody

Manufacturer:  MilliporeSigma™ PC322L100UG

Catalog No. PC322L100UG


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Description

Description

Specifically detects VEGFR1 Clone: in Feline, Human samples, and it is validated for ELISA, Immunohistochemistry (Paraffin), Immuno Blotting

Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF), is a secreted heparin binding cytokine expressed in tumor and animal cells. VEGF has been implicated in the control of angiogenesis due to its selective mitogenic stimulation of vascular endothelial cells and enhancement of vascular permeability. VEGF is a~34-50kDa dimer of two identical disulfide-linked subunits existing in four molecular species; 121, 165, 189, and 206 amino acid residues long, arising from alternative splicing of a single gene. VEGF binds to two receptor tyrosine kinases, Flt-1 (VEGFR1) and KDR/Flk-1 (VEGFR2) found almost exclusively on human endothelial cells. Flt-1 binds VEGF and a new VEGF-related ligand, placenta growth factor (PIGF) but KDR/Flk-1 binds only VEGF. The cDNA encoding the soluble truncated form of Flt-1 cloned from a human endothelial cell library encodes the 6 N-terminal IgG-like extracellular ligand-binding domain but does not encode the transmembrane spanning region and intracellular tyrosine kinase domains. The recombinant soluble receptor binds avidly to VEGF and is a potent VEGF antagonist. Recently, a third VEGF receptor was identified and cloned from tumor cells. This VEGF receptor is isoform-specific, binding VEGF165 but not VEGF121. Studies indicate that this VEGF receptor (VEGF165R) is identical to human neuropilin-1, a receptor for the collapsin/semaphorin family that mediates neuronal cell guidance.
Specifications

Specifications

VEGFR1
Unconjugated
purified
human VEGFR1 (extracellular domain)/Fc chimera
100μg
−20°C
Polyclonal
Feline, Human
ELISA, Immuno Blotting, Immunoblot, Immunohistochemistry (Paraffin)
Lyophilized from a sterile solution in PBS, 5% trehalose.
Goat
IgG
RUO
Primary
Recognizes VEGF receptor 1.
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