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Versican V0, V1 Neo Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA11748A

Catalog No. PA11748A


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Description

Description

PA1-1748A detects versican from human samples. PA1-1748A has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~70 kDa protein representing versican from mouse cumulus oocyte complexes. PA1-1748A immunogen is a synthetic peptide corresponding to residues C G G D(436) P E A A E(441) of human Versican V0/V1 Neo. This sequence is completely conserved between mouse and rat. This immunizing peptide (PEP-235) can be used for neutralization and control experiments. This polyclonal antibody has been referred to as: JSCDPE or DPEAAE.

Versican is a member of the family of large aggregating proteoglycans (also including aggrecan, brevican, and neurocan). The protein shows wide tissue distribution which includes fibrous, articular, and elastic cartilages, as well as nervous, epidermal, arterial, and loose connective tissues. Versican V1 has been shown to enhance cell proliferation, and also induce cell transformation and protect cells from apoptosis. This was demonstrated through its ability to downregulate the expression of proapoptotic Bad. Versican ft.s existence as a extracellular matrix protein in human airways has also lead to the discovery of an inflammatory role in asthmatics.

Abbreviations: AP=Affinity Purification, ChIP=Chromatin IP, CM=Confocal Microscopy, DB=Dot Blot, EIA=ELISA, EM=Electron Microscopy, FC=Flow Cytometry, GS=Gel Supershift, IC=Immunocytochemistry, IF=Immunofluorescence, IH=Immunohistology/Immunohistochemistry, IP=Immunoprecipitation, IPK=IP Kinase Assay, KA=Kinase Assay, NEUT=Neutralization, PIA=Peptide Inhibition Assay, RIA=Radioimmunossay, TCA=T Cell Activation, WB=Western Blotting, Species: Am=Amphibian, Av=Avian, B=Bovine, Ca=Cat ,Ck=Chicken, D=Dog, Dr=Deer, Ds=Drosophila, El=Elk, Fg=Frog, Fs=Fish, Ft=Ferret, G=Goat, Gp=Guinea Pig, H=Horse, Hm=Hamster, Hu=Human, K=Kangaroo, Ms=Mouse, Nhp=Non-Human Primate, O=Ovine, P=Porcine, Rb=Rabbit, Rp=Reptile, Rt=Rat, Ys=Yeast, Xn=Xenopus, (wk)=cross reacts weakly

Specifications

Specifications

Versican V0, V1 Neo
Polyclonal
Unconjugated
VCAN
Liquid
VCAN
Synthetic peptide corresponding to residues C G G D(436) P E A A E(441) of human Versican V0/V1 Neo.
Affinity chromatography
RUO
Antibody
Polyclonal
Human
Western Blot
2 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P13611
GHAP
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
1462
Documents
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