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VG5Q Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA140309

Catalog No. 01-676-428


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Description

Description

PA1-40309 detects VG5Q from human samples. PA1-40309 has been successfully used in ELISA, immunohistochemistry (frozen), immunoprecipitation, immunohistochemistry (paraffin), and Western blot applications. The PA1-40309 imunogen is human VG5Q.

The VG5Q protein (84 kDa) is a potent angiogenic factor that contains a forkhead-associated domain and a G-patch domain. VG5Q functions as an angiogenic factor in promoting angiogenesis and suppression of VG5Q expression inhibits vessel formation. Angiogenic factors are critical to the initiation of angiogenesis and maintece of the vascular network. Angiogenesis has an essential role in pathological conditions such as cancer and various ischaemic and inflammatory diseases. VG5Q can bind to endothelial cells and promote cell proliferation, suggesting that the protein may act in an autocrine fashion. VG5Q interacts with TWEAK (also known as TNFSF12), another secreted angiogenic factor. VG5Q shows strong expression in blood vessels and is secreted when vessel formation is initiated. VG5Q protein was detected mostly in the cytoplasm and around the nuclei of human microvascular endothelial cells (HMVECs). Furthermore VG5Q is detected in human umbilical vein endothelial cells (HUVECs), human heart fibroblast (HHF) and ovarian cancer cells (OV-3), but low expression was detected in kidney cancer cells (RP-45), HeLa Cells and bladder cancer cells.
Specifications

Specifications

VG5Q
Polyclonal
Unconjugated
AGGF1
Liquid
AGGF1
Synthetic human VG5Q peptide
Protein A
RUO
Antibody
Polyclonal
Human
ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
0.1 mg/mL
PBS with 0.1% BSA and 0.02% sodium azide
Q8N302
AGGF1
Rabbit
IgG
100 μg
4° C
Primary
55109
Documents
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