VHL Mouse anti-Human, Unlabeled, Clone: S2-647, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 564183
The S2-647 monoclonal antibody recognizes the Von Hippel-Lindau (VHL) protein. The VHL protein is expressed within the cytosol and nuclei of cells from a variety of tissues. It serves as a tumor suppressor and transcriptional repressor that is highly conserved from Drosophila to mammalian species. VHL binds to Elongin B and C subunits and other proteins as part of a E3 ubiquitin ligase complex that targets a variety of proteins, including HIF-1 alpha and Beta-2 adrenergic receptors, for proteasomal degradation. Aberrant VHL expression is associated with a number of diseases including Von Hippel-Lindau disease, a familial cancer syndrome, that predisposes individuals to hemangioblastomas of the central nervous system and retina, pheochromocytoma and renal cell carcinoma. Three distinct VHL isoforms ranging in molecular weight from approximately 19-30 kDa have been described.
|Aqueous buffered solution containing ≤0.09% sodium azide.|
|VHL1; pVHL; Elongin binding protein; Protein G7; HRCA1; RCA1|
|Human VHL Recombinant Protein|
|Store undiluted at 4°C|
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