MAVS Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520349
A suggested positive control is rat brain tissue lysate. PA5-20349 can be used with blocking peptide PEP-0469.Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappa-B. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKK-a, IKK-b and IKK-iota kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
|A 17 amino acid peptide from near the center of human VISA.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot|
|PBS with 0.02% sodium azide|
|Q7Z434, Q8VCF0, Q66HG9|
|CARDIF, IPS-1, IPS1, VISA; CARD adapter inducing interferon beta; CARD adaptor inducing IFN-beta; IFN-B promoter stimulator 1; interferon beta promoter stimulator protein 1; mitochondrial antiviral-signaling protein; putative NF-kappa-B-activating protein 031N; virus-induced signaling adaptor; virus-induced-signaling adapter|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|228607, 311430, 57506|
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