Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

S-arrestin Rabbit anti-Bovine, Mouse, Ovine, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1731

Catalog No. PA1731


Add to cart

Description

Description

PA1-731 detects recombit bovine and sheep visual arrestin. PA1-731 has been successfully used in immunofluorescence and Western blot procedures. By Western blot this antibody detects an ~57 kDa protein representing recombit bovine and sheep visual arrestin. This antibody also detects a lower molecular weight protein which could correspond to degradation product. The PA1-731 immunizing peptide corresponds to amino acid residues 2-18 from rat visual arrestin. This peptide (Cat. No. PEP-155) is available for use in neutralization and control experiments.

Vision involves the conversion of light into electrochemical signals that are processed by the retina and subsequently sent to and interpreted by the brain. The process of converting light to an electrochemical signal begins when the membrane-bound protein, rhodopsin, absorbs light within the retina. In the active state, rhodopsin activates transducin, a GTP binding protein that promotes the hydrolysis of cGMP by phosphodiesterase (PDE). The decrease of intracellular cGMP concentrations causes the ion channels within the outer segment of the rod or cone to close, thus causing membrane hyperpolarization and, eventually, signal transmission. Rhodopsin’s activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin. Arrestins are cytosolic proteins that are involved in G protein-coupled receptor (GPCR) desensitization. Arrestin binding to activated GPCRs is phosphorylation dependent and, once bound, uncouple the GPCR from the associated heterotrimeric G proteins. There are currently 4 known mammalian isoforms, beta-arrestin1 (arrestin2), beta-arrestin2 (arrestin3), visual arrestin (arrestin1), and cone arrestin. The beta- isoforms are ubiquitously expressed and are known to interact with acetylcholine and adrenergic receptors. Visual and cone arrestins are found to interact directly with transducin.
Specifications

Specifications

S-arrestin
Polyclonal
Unconjugated
Sag
Liquid
Rabbit
IgG
200 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
101105037, 20215, 280922
Immunofluorescence, Western Blot
1 mg/mL
PBS with 1mg/mL BSA and 0.05% sodium azide
P08168, P20443
SAG
Synthetic Peptide: C E(347) V A T E V P F R L M H P Q P E D(363)
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Bovine, Mouse, Ovine
Documents
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit