Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

VDR Rabbit anti-Chicken, Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA1711

Catalog No. PA1711

Add to cart



PA1-711 detects vitamin D receptor (VDR) from human, mouse and rat tissues. PA1-711 has been successfully used in Western blot, immunoprecipitation and gel shift procedures. By Western blot, this antibody detects an ~53 kDa protein representing VDR in COS-7 cells transfected with the human gene. PA1-711 supershifts DNA fragments that contain VDR response elements (e.g., rat osteocalcin and mouse osteopontin upstream elements). PA1-711 immunizing peptide corresponds to amino acid residues 395-413 from human VDR. Recombit human VDR (Cat. No. RP-710) and human RXR beta (catalog No. RP-812) proteins can be purchased separately for control experiments in Western blot, immunoprecipitation and gel shift procedures.

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expresion, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription. The corresponding gene for the vitamin D receptor is NRI1I.


whole serum with 0.05% sodium azide
O42392, P11473, P48281, P13053
VDR, 125 dihydroxyvitamin D3 receptor, NR1I1, Vitamin D3 receptor
Chicken, Human, Mouse, Rat
Gel Shift, Immunoprecipitation, Western Blot
Synthetic Peptide: E(395) E H S K Q Y R C L S F Q P E C S M K(413)
100 μL
-20° C, Avoid Freeze/Thaw Cycles
22337, 24873, 395988, 7421
Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit