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VDR Goat anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Goat Polyclonal Antibody

Manufacturer:  Invitrogen PA19116

Catalog No. 01-674-396


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Description

Description

Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expresion, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription.

This antibody is predicted to react with canine based on sequence homology.
Specifications

Specifications

VDR
Polyclonal
Unconjugated
VDR
Liquid
VDR
Internal sequence corresponding to amino acids CGNQDYKYRVSD.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
peptide-ELISA, Western Blot
0.5 mg/mL
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
P11473, P48281, P13053
VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor ; HGNC:12679; NR1I1; vitamin D (1,25-dihydroxyvitamin D3) receptor
Goat
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
22337, 24873, 7421
Documents
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