VDR Goat anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Goat Polyclonal Antibody
Manufacturer: Invitrogen PA19116
This antibody is predicted to react with canine based on sequence homology.Steroid receptors are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to specific DNA sequences following activation by the appropriate hormone. The 1,25-dihydroxy-vitamin D3 receptor (VDR) belongs to the superfamily of steroid hormone receptors which includes estrogen, progesterone, glucocorticoid, androgen, and thyroid hormone receptors. Vitamin D modulates calcium and phosphorus homeostasis, bone remodeling, cell growth regulation, and differentiation. Studies have found VDR in the intestine, bone, kidney, epidermis, and cells of the endocrine immune system. Repression of T-cell proliferation and interleukin-2 (IL-2) gene expresion, for example, occurs when VDR binds within the IL-2 enhancer. Formation of VDR/retinoic X receptor (RXR) heterodimers in the presence of intracellular 1,25(OH)2D3 has been shown to interfere with assembly of nuclear factor of activated T-cells (NFATp)/Fos/Jun/DNA complex and subsequent IL-2 gene transcription.
|Internal sequence corresponding to amino acids CGNQDYKYRVSD.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3|
|P11473, P48281, P13053|
|VDR; vitamin D (1,25- dihydroxyvitamin D3) receptor ; HGNC:12679; NR1I1; vitamin D (1,25-dihydroxyvitamin D3) receptor|
|-20° C, Avoid Freeze/Thaw Cycles|
|22337, 24873, 7421|
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