VPS53 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA520548
A suggested positive control is 293 cell lysate. PA5-20548 can be used with blocking peptide PEP-0668.The sorting of acid hydrolases to lysosomes rely on mannose 6-phosphate receptors that cycle between the trans-Golgi network (TGN) and endosomes. The maintece of this cycle requires the function of the mammalian Golgi-associated retrograde protein (GARP) complex which is composed of three subunits: VPS52, VPS53, and VPS54. Depletion of any of these three proteins, such as by RNAi, impairs the retrograde transport of multiple TGN proteins. VPS53 was identified as an HIV dependency factor (HDF) and plays a role in viral entry to the cell, suggesting that VPS53 may be an important drug target in HIV treatment. At least five isoforms of VPS53 are known to exist.
|An 18 amino acid peptide from near the carboxy terminus of human VPS53.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|PP13624, HCCS1, hVps53L, pp13624; vacuolar protein sorting-associated protein 53 homolog|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|287535, 55275, 68299|
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