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TRPV2 Rabbit anti-Human, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA118346

Catalog No. 01-670-599


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Description

Description

PA1-18346 detects VRL-1 from human and rat samples. PA1-18346 has been successfully used in immunohistochemistry (paraffin), immunofluorescence, and Western blot procedures. The PA1-18346 immunogen is a synthetic peptide corresponding to residues C-K(744) N S A S E E D H L P L Q V L Q S P(761) of rat VRL-1, conjugated to KLH. After reconstitution keep aliquots at -20°C for a higher stability, and at 4°C with an appropriate antibacterial agent. Reconstitute with 100 µL of distilled water.

VLR-1 is a calcium-permeable, non-selective cation channel with an outward rectification, that seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. VRL-1 does not respond to capsaicin, acid, or moderate heat, but instead is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells. VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. VRL-1 is one of the six members of the vanilloid-like TRP-channel family which is now known as TRPV family.
Specifications

Specifications

TRPV2
Polyclonal
whole serum with no preservative
Q9Y5S1, Q9WUD2
Transient receptor potential cation channel subfamily V member 2, TrpV2, osm-9-like TRP channel 2, OTRPC2, Vanilloid receptor-like protein 1, Stretch-
Rabbit
IgG
RUO
Antibody
Polyclonal
Human, Rat
Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
TRPV2
Lyophilized
TRPV2
Synthetic peptide corresponding to residues C-K(744) N S A S E E D H L P L Q V L Q S P(761) of rat VRL-1.
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
29465, 51393
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