B7-H4 Rabbit anti-Human, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA526803
DescriptionB7-H4 (B7x, VTCN1) a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7-H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7-H4 deficient mice are only minimally affected; suggesting B7-H4 is important in the fine tuning of the T-cell mediated immune response. B7-H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7-H4 is expressed primarily on the membrane of lymphoid cells, and as an immunoinhibitory protein that interacts with receptors on the surface of T lymphocytes, it is involved in mediating cellular and humoral immune responses. Overexpression of B7-H4 is associated with certain maligcies, including ovarian and breast cancer, which may be a mechanism by which tumor cells suppress T cell immunity and facilitate tumor progression. Further, VTCN1 may be a useful biomarker for the early detection of ovarian cancer and Renal Cell Carcinoma (RCC).
|PBS with 0.09% sodium azide|
|B7-H4, B7H4, B7S1, B7X, B7h.5, PRO1291, VCTN1, B7 family member, H4, B7 superfamily member 1, T cell costimulatory molecule B7x, T-cell costimulatory molecule B7x, V-set domain-containing T-cell activation inhibitor 1, immune costimulatory protein B7-H4|
|-20° C, Avoid Freeze/Thaw Cycles|
|KLH conjugated synthetic peptide between 72-100 amino acids from the central region of human VTCN1|
|Antigen affinity chromatography|
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