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WDR48 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524007

Catalog No. PIPA524007


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Description

Description

This antibody is predicted to react with bovine and non-human primate based on sequence homology.

Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 by enhancing the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12 and USP46, respectively. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintece of the viral genome via its interaction with HPV11 helicase E1.
Specifications

Specifications

WDR48
Polyclonal
PBS with 0.09% sodium azide
Q8TAF3
P80, UAF1, USP1 associated factor 1, USP1-associated factor 1, WD repeat endosomal protein, WD repeat-containing protein 48
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
57599
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
WDR48
Liquid
WDR48
KLH conjugated synthetic peptide between 603-630 amino acids from the C-terminal region of human WDR48
Antigen Affinity Chromatography, Protein A
RUO
Antibody
Polyclonal
Human
Documents
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