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XAF1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA141099

Catalog No. 01-675-688


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Description

Description

Suggested positive control: antigen standard for XAF1 (transient overexpression lysate), human liver tissue or protein.

The inhibitors of apoptosis (IAP) proteins prevent cell death both in vitro and in vivo by virtue of inhibition of distinct caspases. The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the IAP family of proteins. The caspase inhibiting activity of XIAP is negatively regulated by at least two XIAP-interacting proteins, XIAP-associated factor 1 (XAF1) and Smac/DIABLO. XAF1 binds to XIAP and antagonizes caspase inhibitory activities of XIAP. Expression of XAF1 triggers a redistribution of XIAP from the cytosol to the nucleus. XAF1 is ubiquitously expressed in normal tissues, but is present at low or undetectable levels in many different cancer cell lines.
Specifications

Specifications

XAF1
Polyclonal
Unconjugated
XAF1
Liquid
XAF1
Synthetic peptides, KLH conjugated, corresponding to residues 201-218 and 301-317 of human XaF1.
Protein G
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q6GPH4, Q5NBU8
BIRC4BP, HSXIAPAF1, XIAPAF1
Rabbit
IgG
100 μg
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Primary
327959, 54739
Documents
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