anti-XPG/ERCC5, Clone: 8H7, Epredia™ LabVision

Mouse Monoclonal Antibody

Supplier:  Epredia MS674P0

Catalog No. MS674P0

Description

Xeroderma pigmentosum type G (XPG) is a human genetic disease exhibiting extreme sensitivity to sunlight. The XPG protein, a member of the flap endonuclease 1 (FEN-1) structure-specific DNA repair endonuclease family, is an enzyme essential for DNA repair of the major kinds of solar ultraviolet (UV)-induced DNA damages. Human XPG nuclease makes the 3' incision during nucleotide excision repair of DNA. The enzyme cleaves model DNA bubble structures specifically near the junction of unpaired DNA with a duplex region. A 29-amino acid region of human XPG (residues 981-1009) contains the PCNA binding activity. A conserved arginine in XPG (Arg992) is crucial for its PCNA binding activity. Replication Protein A (RPA) binds specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA and the endonuclease XPG.

Host Species: Mouse
Clone: 8H7
Isotype: IgG2a/κ
Cross Reactivity: Human. Others-not known.
Epitope: Not determined
Immunogen: Recombinant human XPG protein.
Molecular Weight: 185kDa
Positive Control: Lncap cells.
Cellular Localization: Nuclear

Immunofluorescence, Western Blotting

Specifications

• Antigen: XPG/ERCC5 Ab-1
• Concentration: 200μg/mL
• Host Species: Mouse
• Quantity: 100 μL
• Target Species: Human
• Isotype: IgG2a κ

• Classification: Monoclonal
• Conjugate: Unconjugated
• Immunogen: Recombinant human XPG protein.
• Primary or Secondary: Primary
• Form: Purified