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XRCC1 Mouse anti-Human, Clone: 144, Invitrogen

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA112640

Catalog No. 01-674-024

This item has been discontinued by the manufacturer and is no longer available. Please call customer service for assistance: 1-800-766-7000.


Description

Description

A suggested positive control for this product is HT29, LS174T, HeLa cells or normal testis.

X-Ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNA ligase III through the C-terminal 96 amino acids and to DNA polymerase beta through the N-terminal half. . In testis XRCC1 is expressed at high levels. Cells with a mutation of this gene exhibit decreased single strand break repair and reduced recombination repair. They show increased double strand breaks, and sister chromatid exchange is increased up to 10-fold. The XRCC1 might serve as a scaffold protein during base excision-repair.
Specifications

Specifications

XRCC1
Monoclonal
0.2 mg/mL
PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
P18887
DNA repair protein XRCC1, X-ray repair cross-complementing protein 1, X-ray-repair, complementing defective, repair in Chinese hamster
Mouse
IgG2a, kappa
100μL
4° C
Primary
7515
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
144
Unconjugated
XRCC1
Liquid
XRCC1
Recombit human XRCC1 protein
Protein A
RUO
Antibody
Monoclonal
Human
Documents
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