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Zap-70 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA119390

Catalog No. 01-676-752


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Description

Description

This antibody recognizes the C-terminal part of human ZAP-70 protein tyrosine kinase. ZAP-70 is a molecule susceptible to degradation. It is recommended to use freshly prepared cell lysates (protease inhibitors are essential) to avoid non-specific staining of degradation products

ZAP70, a 70 kDa member of the Syk tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
Specifications

Specifications

Zap-70
Polyclonal
Unconjugated
ZAP70
Liquid
ZAP70
Bacterially expressed fusion protein representing C-terminal part (160 amino acids) of human ZAP-70 with histidine tag
Protein A
RUO
Antibody
Polyclonal
Human
Western Blot
1 mg/mL
PBS with 15mM sodium azide; pH 7.4
P43403
zeta-chain (TCR) associated protein kinase 70kDa
Rabbit
IgG
100 μg
4° C, do not freeze
Primary
7535
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