Zap-70 Mouse anti-Human, Clone: ZAP-03, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA119443
ZAP70, a 70kDa member of the Syk tyrosine kinase family, plays a central role in lymphocyte activation and development, and is implicated in several immune disorders. Upon T cell antigen receptor (TCR) engagement, ZAP70 is phosphorylated on tyrosines 292, 315 and 319 in the interdomain B, located between the SH2 and kinase domains. Phosphorylation of both tyrosines 315 (a Vav binding site) and 319 (a Lck binding site) enhances ZAP70 function in mediating lymphocyte signaling, while tyrosine 292 terminates the transient activation of ZAP70 and attentuates lymphocyte signaling.
|PBS with 15mM sodium azide; pH 7.4|
|zeta-chain (TCR) associated protein kinase 70kDa|
|4° C, do not freeze|
|Flow Cytometry, Immunocytochemistry, Western Blot|
|Bacterially expressed fusion protein representing C-terminal part (160 amino acids) of human ZAP-70 with histidine tag|
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