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ZBTB2 Rabbit anti-Canine, Equine, Human, Marsupial, Mouse, Non-human primate, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA523440

Catalog No. PIPA523440


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Description

Description

ZBTB2 is a member of the POK (POZ domain Krüppel-like zinc finger) family and plays an important role in cell cycle regulation. It is a transcription factor and a potent repressor of the ARF-HDM2-p53-p21 pathway. ZBTB2 represses the transcription of the p21, p53 and ARF genes and activates HDM2 gene. ZBTB2 and Sp1 compete with each other in binding to the GC-box 5/6 elements and the two p53 binding elements. ZBTB2 directly interacted with p53 via its zinc fingers, inhibiting p53 binding and repressing transcription activation by p53.
Specifications

Specifications

ZBTB2
Polyclonal
Unconjugated
ZBTB2
Liquid
ZBTB2
Synthetic peptide (468 CQNQNSDVFALDEGRS 483) of ZBTB2 protein.
Protein A
RUO
Antibody
Polyclonal
Canine, Equine, Human, Marsupial, Mouse, Non-human primate, Rat
Immunohistochemistry (Paraffin), Western Blot
0.5 mg/mL
PBS with 0.05% BSA and 0.05% sodium azide
Q8N680
ZNF437, zinc finger and BTB domain-containing protein 2
Rabbit
IgG
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
100060294, 308126, 381990, 484036, 57621
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