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ZEB2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520980

Catalog No. PIPA520980


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Description

Description

Due to post-translational modifications, ZEB2 migrates at ~180kDa in SDS-PAGE. A suggested positive control is Jurkat cell lysate. PA5-20980 can be used with blocking peptide PEP-1094.

ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.
Specifications

Specifications

ZEB2
Polyclonal
Unconjugated
ZEB2
Liquid
ZEB2
An 18 amino acid peptide near the carboxy terminus of human ZEB2.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
O60315, Q9R0G7
HRIHFB2411, HSPC082, SIP-1, SIP1, SMADIP1, ZFHX1B; SMAD interacting protein 1; Smad-interacting protein 1; zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
24136, 311071, 9839
Documents
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