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ZNF281 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521121

Catalog No. PIPA521121


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Description

Description

A suggested positive control is A-20 cell lysate. PA5-21121 can be used with blocking peptide PEP-1235.

ZFP281, also known as ZBP-99, is a member of a conserved family of transcription factors that interact with GC-rich promoters. It contains four Kruppel-like zinc fingers and is highly homologous to ZBP-89, another regulator of ornithine decarboxylase gene expression. ZFP281 also interacts with many other other transcription factors, such as Sp1 to repress vimentin gene transcription. ZFP281 has also been shown to control embryonic stem cell pluripotency by direct regulating specific target genes. ZFP281 phyically interacts with the transcription factos POU5F1, Sox2, and NANOG. Gene expression microarray anlysis indicated that some ZFP281 target genes were activated, while others were repressed upon knockdown of ZFP281 expression, showing that ZFP281 plays bifuctinal roles in regulating gene expression in stem cells.
Specifications

Specifications

ZNF281
Polyclonal
Unconjugated
ZNF281
Liquid
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
226442, 23528
Immunocytochemistry, Immunofluorescence, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9Y2X9, Q99LI5
Zfp281, ZNF281
A 19 amino acid peptide near the carboxy terminus of human ZFP281.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Documents
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