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ZFYVE19 Mouse anti-Human, Clone: 3G4-2B11, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA522803

Catalog No. PIMA522803


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Description

Description

Peptide Sequence: MESRCYGCAV KFTLFKKEYG CKNCGRAFCS GCLSFSAAVP RTGNTQQKVC KQCHEVLTRG SSANASKWSP PQNYKKRVAA LEAKQKPSTS QSQGLTRQDQ MIAERLARLR QENKPKLVPS QAEIEARLAA LKDERQGSIP STQEMEARLA ALQGRVLPSQ TPQPAHHTPD TRTQAQQTQD LLTQLAAEVA IDESWKGGGP AASLQNDLNQ GGPGSTNSKR QANWSLEEEK SRLLAEAALE LREENTRQER ILALAKRLAM LRGQDPERVT LQDYRLPDSD DDEDEETAIQ RVLQQLTEEA ALDEASGFNI PAEQASRPWT QPRGAEPEAQ DVDPRPEAEE EELPWCCICN EDATLRCAGC DGDLFCARCF REGHDAFELK EHQTSAYSPP RAGQEH

Key regulator of abscission step in cytokinesis: part of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage. Together with CHMP4C, required to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis. Deactivation of AURKB results in dephosphorylation of CHMP4C followed by its dissociation from ZFYVE19/ANCHR and VPS4 and subsequent abscission
Specifications

Specifications

ZFYVE19
Monoclonal
0.2-1.0 mg/mL
PBS with no preservative; pH 7.4
Q96K21
MPFYVE, MLL partner containing FYVE domain, zinc finger FYVE domain-containing protein 19
Mouse
IgG2b, kappa
100 μg
-20° C, Avoid Freeze/Thaw Cycles
Primary
84936
ELISA, Immunoprecipitation, Western Blot
3G4-2B11
Unconjugated
ZFYVE19
Liquid
ZFYVE19
ZFYVE19 (AAH15738.1, 1 a.a. ∽ 396 a.a) full-length recombit protein with GST tag. MW of the GST tag alone is 26 KDa.
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Documents
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