ZIPK Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA112521
A suggested positive control for this product is Jurkat or HeLa whole cell lysate.Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases1. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.
|PBS with 0.02% sodium azide|
|O43293, O54784, O88764|
|-20° C, Avoid Freeze/Thaw Cycles|
|13144, 1613, 64391|
|Synthetic peptide corresponding to residues 279-298 of human ZIP kinase.|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
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