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ZIP1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA521066

Catalog No. PIPA521066


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Description

Description

A suggested positive control is mouse kidney tissue lysate. PA5-21066 can be used with blocking peptide PEP-1180.

ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappa-B, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the maligt potential of prostate cancer cells in vitro and in vivo.
Specifications

Specifications

ZIP1
Polyclonal
Unconjugated
SLC39A1
Liquid
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
27173, 30791
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q9NY26, Q9QZ03
SLC39A1
A 16 amino acid peptide near the amino terminus of human ZIP1.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
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