ZMYM2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA521090
A suggested positive control is rat lung tissue lysate. PA5-21090 can be used with blocking peptide PEP-1204. The immunogen is located within amino acids 120 - 170 of ZMYM2.Zinc-finger proteins contain DNA-binding domains characterized by the unique role of zinc and have a wide variety of functions such as transcriptional activation or repression. The protein folding and the DNA binding ability are governed by the coordination of a zinc ion. As a member of the MYM (myeloproliferative and mental retardation) gene family, ZMYM1 is widely expressed in different tissues in eukaryotes under several forms derived by alternative splicing. While its function remains unknown, the related protein ZMYM2 has been shown to associate with and stabilize the LSD1-CoREST-HDAC1 (LCH) complex of chromatin through its MYM-type zinc fingers, thereby enhancing the transcriptional repression of several genes, suggesting that ZMYM1 may play a similar role.
|A 17 amino acid peptide near the amino terminus of human ZMYM2|
|Antigen affinity chromatography|
|Human, Mouse, Rat|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|PBS with 0.02% sodium azide|
|RP11-264J4.7, FIM, MYM, RAMP, SCLL, ZNF198; fused in myeloproliferative disorders protein; rearranged in an atypical myeloproliferative disorder; zinc finger MYM-type protein 2; zinc finger protein 198|
|Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|305913, 76007, 7750|
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