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Zn-a2-glycoprotein Mouse anti-Human, Unlabeled, Clone: 35, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612354

Catalog No. BDB612354


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Description

Description

Zn-α2-glycoprotein (ZAG) is a soluble protein that was originally isolated from human plasma. ZAG is related to class I major histocompatibility complex (MHC) proteins, which are involved in peptide presentation to cytoxic T-cells during immune surveillance. Besides plasma, ZAG is found in liver, as well as bodily fluids such as sweat, saliva, cerebrospinal fluid, seminal plasm, milk, ammniotic fluid, and urine. In addition, ZAG is found in 40% of breast carcinomas, and in varous tumor cells. In plasma, ZAG lipid binding ability may be important for lipid store homeostasis. Additional functions of ZAG may be involved in the regulation of cell proliferation. In vitro, ZAG has ribonuclease activity that is comparable to onconase and less than Rnase A. ZAG may also regulate cell adhesion, since Tu-138 oral squamouse cells can attach to a ZAG substratum. This attachment inhibits cell proliferation and may involve interaction with integrin α5β1 receptors. Thus, ZAG may be a multi-functional protein involved in lipid storage, cell adhesion, and cell differentiation.

Applications:

Western Blotting

Specifications

Specifications

Zn-a2-glycoprotein
35
Unconjugated
Affinity Purified
Human Zn-α2-glycoprotein aa. 7-102
50μg
Cell Biology
Primary
Human
Western Blot
250μg/mL
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Documents
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