Zn-a2-glycoprotein Mouse anti-Human, Unlabeled, Clone: 35, BD
Mouse Monoclonal Antibody
Manufacturer: BD Biosciences 612354
Zn-α2-glycoprotein (ZAG) is a soluble protein that was originally isolated from human plasma. ZAG is related to class I major histocompatibility complex (MHC) proteins, which are involved in peptide presentation to cytoxic T-cells during immune surveillance. Besides plasma, ZAG is found in liver, as well as bodily fluids such as sweat, saliva, cerebrospinal fluid, seminal plasm, milk, ammniotic fluid, and urine. In addition, ZAG is found in 40% of breast carcinomas, and in varous tumor cells. In plasma, ZAG lipid binding ability may be important for lipid store homeostasis. Additional functions of ZAG may be involved in the regulation of cell proliferation. In vitro, ZAG has ribonuclease activity that is comparable to onconase and less than Rnase A. ZAG may also regulate cell adhesion, since Tu-138 oral squamouse cells can attach to a ZAG substratum. This attachment inhibits cell proliferation and may involve interaction with integrin α5β1 receptors. Thus, ZAG may be a multi-functional protein involved in lipid storage, cell adhesion, and cell differentiation.
|Human Zn-α2-glycoprotein aa. 7-102|
|Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.|
|Store undiluted at -20°C.|
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