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ZO-1 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA524716

Catalog No. PIPA524716


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Description

Description

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
Specifications

Specifications

ZO-1
Polyclonal
Unconjugated
TJP1
Liquid
TJP1
KLH conjugated synthetic peptide between 1570-1600 amino acids from the C-terminal region of human ZO1
Ammonium sulfate precipitation, Size-exclusion - Dialysis
RUO
Antibody
Polyclonal
Human
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
2 mg/mL
PBS with 0.09% sodium azide
Q07157
ZO-1, tight junction protein ZO-1, zona occludens 1, zona occludens protein 1, zonula occludens 1 protein, zonula occludens protein 1
Rabbit
IgG
400 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
7082
Documents
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