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ZRP-1 Mouse, Unlabeled, Clone: 16, BD

Mouse Monoclonal Antibody

Manufacturer:  BD Biosciences 612255

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Catalog No. BDB612255


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Description

Description

Zyxin is a zinc-binding metalloprotein found in focal adhesion plaques. It contains a proline-rich N-terminal domain and a C-terminal domain containing three LIM domains. LIM domains are characterized as zinc-binding motifs involved in gene expression and protein-protein interactions. Zyxin related protein 1 (ZRP-1) was identified through its interaction with the second PDZ domain of PTP1E. ZRP-1 has also been identified as Thyroid Receptor Interacting Protein-6 (TRIP6) during screening for binding partners of the thyroid hormone receptor.
ZRP-1 contains an N-terminal proline-rich region (PRR), and three double zinc finger LIM domains in the C-terminal region. ZRP-1 mRNA has been reported to be widely expressed with strong expression in heart, placenta, lung, liver, kidney, and pancreas. ZRP-1 may interact with focal adhesions similar to other LIM domain proteins in the zyxin-related subfamily. However, ZRP-1 also contains nuclear export signal, and treatment of cells with leptomycin B leads to movement of ZRP-1 from the cytoplasm to the nucleus. Thus, ZRP-1 may be important for relaying signals from focal adhesions to the nucleus.

Western Blotting

Specifications

Specifications

ZRP-1
16
Unconjugated
Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide.
Murine
IgG1
RUO
Store undiluted at -20°C.
Monoclonal
Western Blot
250μg/mL
Zyxin Related Protein-1; TRIP6; Thyroid Receptor Interacting Protein-6
Affinity Purified
Human ZRP-1 aa. 103-209
150μg
Cell Biology
Primary
Human, Murine, Rat
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