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ZSCAN4 Rabbit anti-Human, Mouse, Rat, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA520901

Catalog No. PIPA520901


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Description

Description

A suggested positive control is mouse lung tissue lysate. PA5-20901 can be used with blocking peptide PEP-1015.

Zytotic genome activation (ZGA) is the first and most critical transition event from the maternal genetic to the embryonic genetic program and the major burst of ZGA occurs only in the late 2-cell stage. ZSCAN4 encodes a SCAN domain and four zinc finger domains and is expressed in late 2-cell embryos and embryonic stem cells. Loss-of-function studies using siRNA shows delays in the progression from the 2-cell to the 4-cell stage and subsequent embryo development. ZSCAN4 plays an important role in the preimplantation development. Also, ZSCAN4 is involved in telomere maintece and long term genomic stability in ES cells, suggesting that ZSCAN4 may be of critical importance in maintaining pluripotency in replicating stem cells.
Specifications

Specifications

ZSCAN4
Polyclonal
Unconjugated
ZSCAN4
Liquid
ZSCAN4, ZSCAN4A, ZSCAN4F
An 18 amino acid peptide near the carboxy terminus of human ZSCAN4.
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
1 mg/mL
PBS with 0.02% sodium azide
Q8NAM6, Q3URS2
ZNF494; zinc finger and SCAN domain-containing protein 4; zinc finger protein 494
Rabbit
IgG
100 μg
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Primary
201516, 434555, 503124, 665902
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