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  7. AP 18, Tocris Bioscience™

AP 18, Tocris Bioscience™

Catalog Number p-4783748
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
55224-94-7
C11H12ClNO
209.673
MHTJEUOFLVQMCL-XTYDYKDCSA-N
4-4-chlorophenyl-3-methylbut-3-en-2-oxime
16725814
(NE)-N-[(Z)-4-(4-chlorophenyl)-3-methylbut-3-en-2-ylidene]hydroxylamine
CC(=CC1=CC=C(C=C1)Cl)C(=NO)C
This item is not returnable. View return policy
55224-94-7
C11H12ClNO
209.673
MHTJEUOFLVQMCL-XTYDYKDCSA-N
4-4-chlorophenyl-3-methylbut-3-en-2-oxime
16725814
(NE)-N-[(Z)-4-(4-chlorophenyl)-3-methylbut-3-en-2-ylidene]hydroxylamine
CC(=CC1=CC=C(C=C1)Cl)C(=NO)C

Description

Reversible TRPA1 channel blocker

AP 18 is a reversible TRPA1 channel blocker (IC50 values are 3.1 and 4.5 μM at human and mouse TRPA1 respectively). Blocks cinnamaldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo. Also blocks TRPA1 pore dilation (IC50 = 10.3 μM for the inhibition of Yo-Pro uptake).
Quantity 10 mg
Formula Weight 209.67
Percent Purity >98%
Chemical Name or Material AP 18

Safety and Handling

Recommended Storage Store at +4°C
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