AP1/JUN/P39 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 221141AP
DescriptionFos and Jun dimerize to form Activator Protein-1 (AP-1), a transcriptional factor that binds to the 12-O-tetradecanoylphorbol 13-acetate (TPA) response element (TRE) of several cellular and viral genes including human collagenase, metallothionein IIa, stromelysin, interleukin 2, SV40 and polyoma. Fos and Jun contain the ft.leucine-zipper ft. motif that allows for dimerization and an adjacent basic domain required for biological activity. The functionally active form of Fos is in a heterodimer with a member of the Jun family. While Jun family members can form functional homodimers, studies indicate that Fos family members do not self-associate and therefore do not bind DNA on their own. The various dimers differ in their ability to transactivate AP-1 dependent genes.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P05412, P05627, P17325|
|Activator protein 1, AP 1, AP1, c Jun, JUN, jun oncogene, P39, Proto oncogene c Jun, Transcription factor AP 1|
|16476, 24516, 3725|
|Immunocytochemistry, Immunofluorescence, Western Blot|
|AP1,JUN,P39 Fusion Protein Ag17419|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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