AP2M1 Monoclonal Antibody (OTI1E9), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA503019

Catalog No. 50-167-3997

Description

The heterotetrameric coat assembly protein complex, also known as the adaptor-related protein complex 2 (AP-2), belongs to the adaptor complexes medium subunits family. The mu 1 subunit of the AP-2 complex (AP2M1) is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. AP2M1 has also been shown to associate with the HIV-1 protein Nef, suggesting that Nef may use AP-2 complex to enhance the rate of endocytosis of both CD4 and class I MHC. AP2M1 may also play an important role in regulating the intracellular trafficking and function of cytotoxic T-lymphocyte associated (CTLA)-4 protein. At least two isoforms of AP2M1 are known to exist.

Specifications

• Antigen: AP2M1
• Classification: Monoclonal
• Concentration: 0.65 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P84091, P84092, Q96CW1
• Gene Symbols: Ap2m1
• Immunogen: Human recombit protein fragment corresponding to amino acids 97-383 of human AP2M1 produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Canine, Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1E9
• Conjugate: Unconjugated
• Gene: AP2M1
• Gene Alias: AP50, CLAPM1, mu2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 116563, 1173, 11773, 607139
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid