APC1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 217481AP
DescriptionCell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|ANAPC1, APC1, Mitotic checkpoint regulator, TSG24|
|17222, 311412, 64682|
|Immunohistochemistry (Paraffin), Western Blot|
|APC1 Fusion Protein Ag13399|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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