APC11 Mouse anti-Human, Clone: OTI1B11, Invitrogen
Mouse Monoclonal Antibody
Manufacturer: Invitrogen MA526264
DescriptionCell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC11 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. APC11, together with APC2 and Ubc4, form the minimal APC ubiquitin ligase module.
|PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3|
|HSPC214, APC11, Apc11p; APC11 anaphase promoting complex subunit 11 homolog; anaphase promoting complex subunit 11 (yeast APC11 homolog); anaphase-promoting complex subunit 11; cyclosome subunit 11; hepatocellular carcinoma-associated RING finger protein|
|-20° C, Avoid Freeze/Thaw Cycles|
|Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot|
|Full length human recombit protein of ANAPC11 produced in HEK293T cell|
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