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Aphidicolin, >99%, MP Biomedicals™
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- It is an antibiotic, a potent antiviral and antimitotic agent and DNA polymerase inhibitor.
- Inhibits the early S-phase of the cell cycle. DNA polymerase α and δ reversible inhibitor.
- Potentiates apoptosis induced by arabinosyl nucleosides in leukemia cell lines.
- Also induces apoptosis in HeLa S3 cells, but inhibits vincristine-induced apoptosis in the p53-negative human prostate cancer cell line PC-3.
|Optical Rotation||[α]27/D +12°, c = 1 in methanol (Lit.)|
|Melting Point||227°C to 233°C (literature)|
|Solubility Information||Soluble in DMSO ethanol (50mg/mL ) and soluble in methanol (10mg/mL - clear, colorless solution).|
|Physical Form||Free Flowing Powder|