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APIP Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550193

Catalog No. PA550193


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Description

Description

The antibody detects endogenous levels of total APIP protein.

The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf 1 (for apoptosis protease-activating factor 1) (1,2). Apaf 1 binds to cytochrome c (Apaf 2) and Caspase-9 (Apaf 3), which leads to Caspase-9 activation. Activated Caspase-9 in turn cleaves and activates Caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (3). Recently, Cho et al (4) have identified a new Apaf 1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf 1. APIP is predicted to code for a 204 amino acid. An isoform of APIP, APIP2 encodes a 242 amino acid protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney.
Specifications

Specifications

APIP
Polyclonal
Unconjugated
APIP
Liquid
APIP
Fusion protein corresponding to a region derived from internal residues of human Probable methylthioribulose-1-phosphate dehydratase
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
1.6 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q96GX9, Q9WVQ5
APIP2, CGI29, CGI-29, MMRP19, dJ179L10.2
Rabbit
IgG
100 μL
-20°C
Primary
51074, 56369
Documents
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