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APOB48R Mouse anti-Human, Clone: OTI1B5, Invitrogen™

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen MA526836

Catalog No. PIMA526836


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Description

Description

ApoB48R (apolipoprotein B48 receptor), also known as apolipoprotein B-100 receptor, is a 1,088 amino acid protein that functions as a macrophage receptor by binding to apoB of dietary triglyceride-rich lipoproteins or to a similar apoB-like domain in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). ApoB48R may contribute necessary lipids, lipid-soluble vitamins and other nutrients to reticuloendothelial cells. Significantly elevated plasma triglyceride levels may cause apoB48R to be a factor in foam cell formation, endothelial dysfunction and atherothrombogenesis. ApoB48R also mediates the swift, high-affinity uptake of chylomicrons, HTG-VLDL and trypsinized VLDL lacking apoE in in vitro macrophages. Conserved in chimpanzee, dog, cow, mouse and rat, apoB48R is ubiquitously expressed in all tissues, except skeletal muscle, with high expression in lung and placenta, and low expression in brain and heart. ApoB48R is encoded by a gene that maps to human chromosome 16p11.2 and exists as three alternatively spliced isoforms.
Specifications

Specifications

APOB48R
Monoclonal
1 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Q0VD83
Apolipoprotein B receptor; Apolipoprotein B-100 receptor; Apolipoprotein B-48 receptor; Apolipoprotein B48 receptor; apoB-48R; APOBR; APOB48R
Mouse
IgG1
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
55911
Immunohistochemistry (Paraffin), Western Blot
OTI1B5
Unconjugated
APOBR
Liquid
APOBR
Human recombit protein fragment corresponding to amino acids 780-1088 of APOBR produced in E.coli
Affinity Chromatography
RUO
Antibody
Monoclonal
Human
Documents
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