Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

APP (Amyloid Precursor Protein) Mouse anti-Human, Mouse, Rat, Clone: 22C11, eBioscience™ Non-distribution product as customer accommodation.

Mouse Monoclonal Antibody

Manufacturer:  Invitrogen 14974980

 View more versions of this product

Catalog No. 50-112-2817


Add to cart

Description

Description

Description: The monoclonal antibody 22C11 recognizes human, mouse, and rat APP (Amyloid Precursor Protein). APP is expressed in high abundance in the central nervous system and has three major isoforms resulting from alternative splicing. APP plays a role in synaptic formation and repair, anterograde neuronal transport, iron export, and hormonal regulation. Secreted APP (sAPP) may have neuroprotective effects against neurotoxic insult, oxidative stress, and excitotoxicity. APP belongs to a family that contains at least two homologs, amyloid precursor-like proteins 1 and 2 (APLP1 and APLP2). Similarities between APP and APLP, especially APLP2, suggest that APLP could share and compensate for the function of APP. Proteolytic cleavage of APP results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer ft.s disease. Abnormal regulation and processing of APP also plays a role in Down ft.s syndrome, early onset familial Alzheimer ft.s disease, cerebral hemorrhage, and arthritis. This 22C11 antibody reacts with pre-A4 and recognizes all three isoforms of APP (immature, sAPP, and mature). This 22C11 antibody is known to cross react with APLP2. Applications Reported: This 22C11 antibody has been reported for use in microscopy, and immunocytochemistry.

Applications Tested: This 22C11 antibody has been tested by immunocytochemistry of methanol-fixed cells and can be used at less than or equal to 2.5 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 µm post-manufacturing filtered. Amyloid Precursor Protein (APP) or Amyloid beta protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1; APP is rapidly internalized via clathrin-coated pits. APP is important for neurite growth, neuronal adhesion and axonogenesis. Mutations in the APP gene can lead to Alzheimer disease 1 (AD1). This anitbody recognizes APP (b-APP770) with a MW of approximately 100kDa.
Specifications

Specifications

APP (Amyloid Precursor Protein)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P05067, P12023, P08592
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human, Mouse, Rat
Immunocytochemistry, Immunofluorescence, Immunohistochemistry
22C11
Unconjugated
APP
Liquid
APP
IgG1, kappa
25 μg
4° C
Primary
11820, 351, 54226
Documents
Provide Content Correction

The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit

For Research Use Only.